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Jeudi 27 Janvier 2011 - Mickael Primig - Inserm unit 625 Rennes 1 Print
Written by Pierre PETERLONGO   

The meiotic developmental program

10h30 Salle Aurigny

SLIDES
Meiosis is a key developmental pathway essential for sexual reproduction of most eukaryotes. It is triggered by external stimuli in a diploid yeast or mammalian germ cell and leads to the production of haploid gametes. While much is known about the conserved protein-coding genes involved in the meiotic process the structure, expression and function of noncoding RNAs (ncRNAs) is only poorly understood. We have used a novel type of microarray to determine the complete transcriptome of the budding yeast life cycle and find that protein-coding and noncoding expression programs are largely interleaved via sense/antisense pairs and bidirectional promoters. Critically, our studies revealed that the conserved exoribonuclease Rrp6 targets meiotic ncRNAs during mitosis and that the protein is itself degraded during the onset of meiosis when ncRNAs start to accumulate. Based on our data we suggest a model for a mechanism that ensures coordinated accumulation of mRNAs and ncRNAs during gametogenesis. 
 
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